Structure of PDB 7fd4 Chain D

Receptor sequence

>7fd4D (length=779) Species: 172827 (Meiothermus taiwanensis)

RLELPVIPLRNTVILPHTTTPVDVGRAKSKRAVEEAMGADRLIFLVAQRD
PEVDDPAPDDLYTWGVQAVVKQAMRLPDGTLQVMVEARARAQVTDYIPGP
YLRARGEVFSEIFPIDEAVVRVLVEELKEAFEKYVANHKSLRLDRYQLEA
VKGTSDPAMLADTIAYHATWTVAEKQEILELTDLEARLKKVLGLLSRDLE
RFELDKRVAQRVKEQMDTNQREYYLREQMKAIQKELGGEDGLSDLEALRK
KIEEVGMPEAVKTKALKELDRLERMQQGSPEATVARTYLDWLTEVPWSKA
DPEVLDINHTRQVLDEDHYGLKDVKERILEYLAVRQLTQGLDVRNKAPIL
VLVGPPGVGKTSLGRSIARSMNRKFHRISLGGVRDEAEIRGHRRTYIGAM
PGKLIHAMKQVGVINPVILLDEIDKMSSDWRGDPASAMLEVLDPEQNNTF
TDHYLDVPYDLSKVFFITTANTLQTIPRPLLDRMEVIEIPGYTNMEKQAI
ARQYLWPKQVRESGMEGRIEVTDAAILRVISEYTREAGVRGLERELGKIA
RKGAKFWLEGAWEGLRTIDASDIPTYLGIPRYRPDKAETEPQVGTAQGLA
WTPVGGTLLTIEVAAVPGSGKLSLTGQLGEVMKESAQAALTYLRAHTQDY
GLPEDFYNKVDLHVHVPDGATPKDGPSAGITMATAIASALSRRPARMDIA
MTGEVSLRGKVMPIGGVKEKLLAAHQAGIHKIVLPKDNEAQLEELPKEVL
EGLEIKLVEDVGEVLEYLLLPEPTMPPVV

3D structure

• PDB: 7fd4 Complete three-dimensional structures of the Lon protease translocating a protein substrate.
• Chain: D
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.53: endopeptidase La.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	Y397 I398 R432	Y396 I397 R431
BS02	AGS	D	E446 R484	E445 R483
BS03	ADP	D	H319 Y320 G358 V359 G360 K361 S363 Y493 V540 R541	H318 Y319 G357 V358 G359 K360 S362 Y492 V539 R540
BS04	4KZ	D	L600 A601 W602 T603 L610 M633 T672 P673 K674 D675 G676 S678 K721	L599 A600 W601 T602 L609 M632 T671 P672 K673 D674 G675 S677 K720

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005524 ATP binding
• GO:0008236 serine-type peptidase activity
• GO:0016887 ATP hydrolysis activity
• GO:0042802 identical protein binding
• GO:0043565 sequence-specific DNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0030163 protein catabolic process
• GO:0034605 cellular response to heat

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7fd4, PDBe:7fd4, PDBj:7fd4
• PDBsum: 7fd4
• PubMed: 34652947
• UniProt: A0A059VAZ3