Structure of PDB 7f7i Chain D

Receptor sequence
>7f7iD (length=182) Species: 10116 (Rattus norvegicus) [Search protein sequence]
HYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYH
FVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVS
ANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLE
QEFTECFSAIVEGDSFEEIYHKVKRVIEDLSG
3D structure
PDB7f7i Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
ChainD
Resolution2.595 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D H532 Y533 H642 H644 L711 G713 H1 Y2 H111 H113 L180 G182
BS02 peptide D D545 N548 D549 G560 S561 P564 R568 R571 E600 A601 G602 Y604 Y609 G610 T611 D14 N17 D18 G29 S30 P33 R37 R40 E69 A70 G71 Y73 Y78 G79 T80
External links
PDB RCSB:7f7i, PDBe:7f7i, PDBj:7f7i
PDBsum7f7i
PubMed34458841
UniProtP31016|DLG4_RAT Disks large homolog 4 (Gene Name=Dlg4)

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