Structure of PDB 7f75 Chain D

Receptor sequence
>7f75D (length=1142) Species: 1423 (Bacillus subtilis) [Search protein sequence]
LDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKDGLFCERI
FGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPV
SHIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLS
EKEYRAYLDKYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQ
RRTRAIKRLEVLEAFRNSGNKPSWMILDVLPVIPPELRPMVQLDGGRFAT
SDLNDLYRRVINRNNRLKRLLDLGAPSIIVQNEKRMLQEAVDALIDNGRR
GRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPHLK
MYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIERVQPEVWDVL
ESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADFD
GDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYY
LTLERAGAVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLQRSKLLI
TTVGKLVFNEILPESFPYMNEPTKSNIEEDVKAVIAQQPINAPFKKGILG
KIIAEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQE
ILEEAQSKVDNVMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLD
ELNPIYMMSDSGARGNASNFTQLAGMRGLMANPAGRIIELPIKSSFREGL
TVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIIRETDCGTD
RGILAKPLKEGTETIERLEERLIGRFARKQVKHPETGEVLVNENELIDED
KALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVEVGEAVGI
IAAQSIGEPGTQLTGLPRIQELFEARNPATITEIDGTVVEINEVRDKQQE
IVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSIDPKELLKVTDL
TTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVGDTDVLPGTL
LDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETT
RVLTDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKP
3D structure
PDB7f75 Structural basis of transcription activation by the global regulator Spx.
ChainD
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D Y36 R37 Y35 R36
BS02 dna D R248 R300 K323 R341 A415 P416 T794 A795 R247 R299 K322 R340 A414 P415 T773 A774
BS03 MG D D449 D451 D448 D450
BS04 ZN D C75 V80 C74 V79
BS05 ZN D C892 C899 C902 C871 C878 C881
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f75, PDBe:7f75, PDBj:7f75
PDBsum7f75
PubMed34530448
UniProtP37871|RPOC_BACSU DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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