Structure of PDB 7ezm Chain D

Receptor sequence
>7ezmD (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
EWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSD
LMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISL
ERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTK
NNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELY
QGIKFEASQKKSNRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFS
ANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGF
MATF
3D structure
PDB7ezm Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D P101 K105 G122 V125 Y176 C196 R197 F198 H210 N333 R336 E344 L347 S348 I352 Y360 P64 K68 G85 V88 Y139 C159 R160 F161 H173 N252 R255 E263 L266 S267 I271 Y279
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004951 cholecystokinin receptor activity
GO:0017046 peptide hormone binding
GO:0042277 peptide binding
Biological Process
GO:0001764 neuron migration
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0030900 forebrain development
GO:0032870 cellular response to hormone stimulus
GO:0038188 cholecystokinin signaling pathway
GO:0046883 regulation of hormone secretion
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ezm, PDBe:7ezm, PDBj:7ezm
PDBsum7ezm
PubMed
UniProtP32238|CCKAR_HUMAN Cholecystokinin receptor type A (Gene Name=CCKAR)

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