Structure of PDB 7exm Chain D

Receptor sequence
>7exmD (length=274) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
TRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCR
EHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIK
TIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQ
TGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEH
SLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIG
CNHTGVVGEGSEGLNDNLLEILQK
3D structure
PDB7exm Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2.
ChainD
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C21 C52 H55 H57 C18 C49 H52 H54
BS02 ZN D C144 C147 C162 C165 C141 C144 C159 C162
BS03 ZN D C191 C194 H203 C237 C188 C191 H200 C234
External links
PDB RCSB:7exm, PDBe:7exm, PDBj:7exm
PDBsum7exm
PubMed34398430
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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