Structure of PDB 7eu7 Chain D

Receptor sequence

>7eu7D (length=781) Species: 9606 (Homo sapiens)

LNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLI
THVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASM
IMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREF
ISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSK
DEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDD
WDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHT
LHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTL
SLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNT
VPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG
KHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGI
SVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFTIGK
AIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM
IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQ
YMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSG
YIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNE
KLDIDNMAGVFYMLAAAMALSLITFIWEHLF

3D structure

• PDB: 7eu7 Structural basis of ketamine action on human NMDA receptors.
• Chain: D
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLU	D	H485 L512 T513 R518 G688 Y730 D731	H452 L479 T480 R485 G635 Y677 D678
BS02	JC9	D	L642 T646	L589 T593

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0015276 ligand-gated monoatomic ion channel activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006811 monoatomic ion transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7eu7, PDBe:7eu7, PDBj:7eu7
• PDBsum: 7eu7
• PubMed: 34321660
• UniProt: Q12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)