Structure of PDB 7dxf Chain D

Receptor sequence

>7dxfD (length=685) Species: 9606 (Homo sapiens) [Search protein sequence]

LSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANE
HLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLDD
FYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKC
NDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELA
VLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQS
GDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAV
KFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLG
LLVMNAADRFEGTFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKE
YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDNVKYYNLARIK
WDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIF
KFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGL
SEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE
DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPRQYQKIMKRLIKRYVLQ
AQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQ

3D structure

PDB

7dxf Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	W99	D	I640 M643 V644 F648	I505 M508 V509 F513
BS02	98R	D	Y705 V710	Y570 V575
BS03	CA	D	E878 N880 E883	E659 N661 E664
BS04	Y01	D	F699 N702 I703	F564 N567 I568
BS05	ZN	D	H249 C255 C258	H144 C150 C153
BS06	W99	D	S608 L627 G628	S473 L492 G493
BS07	Y01	D	M403 F407 V410 T451 I613 N617	M298 F302 V305 T346 I478 N482
BS08	CA	D	E144 D890	E50 D671
BS09	CA	D	E509 E512	E389 E392
BS10	Y01	D	A539 M546 I594	A419 M426 I459
BS11	98R	D	V631 E672 F675 K676 F679	V496 E537 F540 K541 F544

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005261	monoatomic cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0042803	protein homodimerization activity
GO:0070679	inositol 1,4,5 trisphosphate binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006812	monoatomic cation transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007338	single fertilization
GO:0032414	positive regulation of ion transmembrane transporter activity
GO:0051480	regulation of cytosolic calcium ion concentration
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0034703	cation channel complex
GO:0036057	slit diaphragm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7dxf, PDBe:7dxf, PDBj:7dxf
PDBsum	7dxf
PubMed	35051376
UniProt	Q9Y210\|TRPC6_HUMAN Short transient receptor potential channel 6 (Gene Name=TRPC6)

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