Structure of PDB 7ddf Chain D

Receptor sequence

>7ddfD (length=285) Species: 9823 (Sus scrofa) [Search protein sequence]

KKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTIS
EFKPTYQDRVAPPGLTQIPQSQKTEISFRPNDPQSYESYVVSIVRFLEKY
KDLAQKDDMIFEDCGNVPSELKERGEYNNERGERKVCRFRLEWLGNCSGG
YKDGKPCVIIKLNRVLGFKPKPPKNESLETYPVMKYNPYVLPVHCTGKRD
EDKEKVGTMEYFGLGGYPGFPLQYYPYYGKLLQPKYLQPLMAVQFTNLTM
DTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

3D structure

PDB

7ddf Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.

Chain

Resolution

4.62 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	D	R27 I35 Y39 Y43	R15 I23 Y27 Y31

Gene Ontology

	Molecular Function
GO:0001671	ATPase activator activity
GO:0005391	P-type sodium:potassium-exchanging transporter activity
GO:0005515	protein binding
GO:0030674	protein-macromolecule adaptor activity
GO:0051117	ATPase binding

	Biological Process
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006883	intracellular sodium ion homeostasis
GO:0007155	cell adhesion
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0030007	intracellular potassium ion homeostasis
GO:0036376	sodium ion export across plasma membrane
GO:0045087	innate immune response
GO:0055085	transmembrane transport
GO:0086009	membrane repolarization
GO:1902600	proton transmembrane transport
GO:1903278	positive regulation of sodium ion export across plasma membrane
GO:1903288	positive regulation of potassium ion import across plasma membrane
GO:1903408	positive regulation of P-type sodium:potassium-exchanging transporter activity
GO:1990573	potassium ion import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0016324	apical plasma membrane
GO:0042383	sarcolemma

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7ddf, PDBe:7ddf, PDBj:7ddf
PDBsum	7ddf
PubMed	33318128
UniProt	P05027\|AT1B1_PIG Sodium/potassium-transporting ATPase subunit beta-1 (Gene Name=ATP1B1)

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