Structure of PDB 7cxn Chain D

Receptor sequence
>7cxnD (length=186) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
FSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAM
QRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN
IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE
IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA
3D structure
PDB7cxn Architecture of a SARS-CoV-2 mini replication and transcription complex.
ChainD
Resolution3.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D R51 A54 R46 A49
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:7cxn, PDBe:7cxn, PDBj:7cxn
PDBsum7cxn
PubMed33208736
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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