Structure of PDB 7ctf Chain D

Receptor sequence
>7ctfD (length=406) Species: 9606 (Homo sapiens) [Search protein sequence]
TECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSV
LIIGPRGSGKTMLINHALKELMEIEESENVLQVHLNGLLQINDKIALKEI
TRQLNLENVVGDKVFGSFAENLSFLLEALKKGCPVIFILDEFDLFAHHKN
QTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMN
SFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKH
FNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVH
GLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEK
PVVMKAFEHLQQLELIKPMQREYQLMKLLLDNTQIMNALQKYPNCPTDVR
QWATSS
3D structure
PDB7ctf Structural insight into the assembly and conformational activation of human origin recognition complex.
ChainD
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP D H34 L37 F38 V40 R69 G70 S71 G72 K73 T74 M75 L276 R277 H21 L24 F25 V27 R56 G57 S58 G59 K60 T61 M62 L257 R258
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0040038 polar body extrusion after meiotic divisions
GO:0051258 protein polymerization
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ctf, PDBe:7ctf, PDBj:7ctf
PDBsum7ctf
PubMed33298899
UniProtO43929|ORC4_HUMAN Origin recognition complex subunit 4 (Gene Name=ORC4)

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