Structure of PDB 7cmc Chain D

Receptor sequence
>7cmcD (length=301) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
EGVEVKGPWLDDAQSLEEVVSYYYRIGFQATHLGRAIEIWRKVEEKRERG
EEIRVFLGYTSNIISSGLREIIAWLVKEKKVDVIVTTAGGVEEDFIKSLK
PFILGDKGVNRIGNIFVPNDRYIEFEKYMIPFFERVLKIEEKLSRPLTAS
EFIYEMGRYMDEKLGKEKEKSVIYWAYKNNIPIFCPAITDGSIGDMLYFF
KEERRDSRLIIDIANDIVKLNNLAITAKETASIILGGSLPKHAIINANLF
RGGTDYAIYISTAVPWDGSLSGAPPRADYVEVWGDATLIFPILVWMVMKA
R
3D structure
PDB7cmc Flexible NAD+Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E107 H266
Catalytic site (residue number reindexed from 1) E93 H242
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D S262 H266 D291 S293 L294 S295 S238 H242 D267 S269 L270 S271
BS02 NAD D T74 S75 T101 A102 G103 E106 E107 G260 G261 S262 S285 T286 A287 D320 A321 T60 S61 T87 A88 G89 E92 E93 G236 G237 S238 S261 T262 A263 D285 A286
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
Biological Process
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7cmc, PDBe:7cmc, PDBj:7cmc
PDBsum7cmc
PubMed32752130
UniProtO50105|DHYS_PYRHO Probable deoxyhypusine synthase (Gene Name=dys)

[Back to BioLiP]