Structure of PDB 7cbk Chain D

Receptor sequence
>7cbkD (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRA
VRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATI
NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTS
LCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYP
DAFAPVAQFVNWIDSIIQ
3D structure
PDB7cbk Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site.
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 F192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H41 D88 F170 G171 D172 S173
Enzyme Commision number 3.4.21.37: leukocyte elastase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC D W27 V200 C201 N204 G205 W12 V178 C179 N180 G181
BS02 MG D G189 V190 C220 D226 G167 V168 C194 D201
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7cbk, PDBe:7cbk, PDBj:7cbk
PDBsum7cbk
PubMed32657577
UniProtP08246|ELNE_HUMAN Neutrophil elastase (Gene Name=ELANE)

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