Structure of PDB 7by9 Chain D

Receptor sequence
>7by9D (length=311) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
AMKRKKISVIGAGFTGATTAFLLAQKELGDVVLVDIPQLENPTKGKALDM
LEASPVLGFDANIIGTSDYADTADSDIVVITAGIARKPGMSRDDLVTTNQ
KIMKQVTKEVVKYSPNCYIIVLTNPVDAMTYTVFKESGFPKNRVIGQSGV
LDTARFRTFVAEELNISVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLEKL
IPKDRLDAIVERTRKGGGEIVNLLGNGSAYYAPAASLVEMVEAILKDQRR
ILPAIAYLEGEYGYEGIYLGVPTILGGNGIEKVIELELTEEEKAALAKSV
ESVKNVMRMLE
3D structure
PDB7by9 Structural analysis and reaction mechanism of malate dehydrogenase from Geobacillus stearothermophilus.
ChainD
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G11 G13 F14 T15 D35 I36 T81 A82 Q105 L122 T123 N124 Q147 H179 P233 G11 G13 F14 T15 D35 I36 T81 A82 Q105 L122 T123 N124 Q147 H179 P233
BS02 OAA D N124 L151 R155 N124 L151 R155
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase (NAD+) activity
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7by9, PDBe:7by9, PDBj:7by9
PDBsum7by9
PubMed33723609
UniProtA0A143T1U9

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