Structure of PDB 7bgn Chain D

Receptor sequence
>7bgnD (length=203) Species: 3880 (Medicago truncatula) [Search protein sequence]
NAVDSLLDSVKWDNKGLAVAIAQNVDTGAILMQGFANREAVATTISSRKA
TFYSRSRSSLWTKGETSNNFINVHDVFLDCDRDSIIYLGKPDGPTCHTGA
ETCYYTPVFDLNKLALTSLYALESTISQRKAEVSWTKRLLLNDKLLCSKI
REEANELCETLENNEDKSRTASEMADVLYHAMVLLALKDVKVEEVLQVLR
QRF
3D structure
PDB7bgn Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.-.-.-
3.5.4.19: phosphoribosyl-AMP cyclohydrolase.
3.6.1.31: phosphoribosyl-ATP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP D R263 F264 R202 F203
BS02 ZN D C142 C149 C96 C103
BS03 ZN D D125 D127 D129 D79 D81 D83
BS04 ZN D E214 E234 D237 E153 E173 D176
BS05 AMP D R183 S195 W196 T197 Y240 R129 S134 W135 T136 Y179
BS06 AMP D R103 W107 K109 G110 T112 S113 T141 C142 H143 C149 R57 W61 K63 G64 T66 S67 T95 C96 H97 C103
Gene Ontology
Molecular Function
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 phosphoribosyl-ATP diphosphatase activity
Biological Process
GO:0000105 L-histidine biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7bgn, PDBe:7bgn, PDBj:7bgn
PDBsum7bgn
PubMed33958623
UniProtA0A072U2X9

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