Structure of PDB 7ay0 Chain D

Receptor sequence
>7ay0D (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
NNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIIYELICSLQSLIISVEQL
QASFLLNPTQPRRLLNTLRELNPMDAQEVLQCILGNIQETCQLLKKVEKL
FQGQLVLRTRCLECESLTERREDFQDISVPVQEDEEMKTLRWAISQFASV
ERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEGGLS
KINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
WLLFDDSEVKVTEEKDFLNSLSPTSTPYLLFYKKL
3D structure
PDB7ay0 Structural basis of FANCD2 deubiquitination by USP1-UAF1.
ChainD
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C440 C443 C506 C509 C111 C114 C161 C164
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0006282 regulation of DNA repair
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:7ay0, PDBe:7ay0, PDBj:7ay0
PDBsum7ay0
PubMed33795880
UniProtO94782|UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (Gene Name=USP1)

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