Structure of PDB 7agd Chain D

Receptor sequence
>7agdD (length=339) Species: 5480 (Candida parapsilosis) [Search protein sequence]
DSISLSLINEGPSYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNAQCGKG
VDCKSSGTFTPSSSSSYKNLGAAFTIRYGDGSTSQGTWGKDTVTINGVSI
TGQQIADVTQTSVDQGILGIGYTSNEAVYDTSGRQTTPNYDNVPVTLKKQ
GKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTSSQALTIS
LASVNLKGSSFSFGDGALLDSGTTLTYFPSDFAAQLADKAGARLVQVARD
QYLYFIDCNTDTSGTTVFNFGNGAKITVPNTEYVYQNGDGTCLWGIQPSD
DTILGDNFLRHAYLLYNLDANTISIAQVKYTTDSSISAV
3D structure
PDB7agd Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
ChainD
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 D37 W39 Y78 D220 T223
Catalytic site (residue number reindexed from 1) D32 S35 D37 W39 Y78 D220 T223
Enzyme Commision number 3.4.23.24: candidapepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D D32 G34 R77 Y78 G79 D80 N125 A127 D220 G222 T223 T224 Y285 D32 G34 R77 Y78 G79 D80 N125 A127 D220 G222 T223 T224 Y285
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:7agd, PDBe:7agd, PDBj:7agd
PDBsum7agd
PubMed33843395
UniProtP32951|CARP1_CANPA Candidapepsin-1 (Gene Name=SAPP1)

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