Structure of PDB 7a2g Chain D

Receptor sequence
>7a2gD (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
GKAMLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPH
LEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCH
HLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE
EIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSR
FLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPD
CCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFG
LCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTY
QSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRR
SLEGVQDELDTLAHALSAIG
3D structure
PDB7a2g Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
ChainD
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.16.2: tyrosine 3-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE D H330 E331 H335 E375 H253 E254 H258 E298
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004511 tyrosine 3-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process
GO:0042423 catecholamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7a2g, PDBe:7a2g, PDBj:7a2g
PDBsum7a2g
PubMed35013193
UniProtP07101|TY3H_HUMAN Tyrosine 3-monooxygenase (Gene Name=TH)

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