Structure of PDB 6zbn Chain D

Receptor sequence
>6zbnD (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
PLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGGDK
ITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPG
NGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFAD
IEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLT
3D structure
PDB6zbn Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
ChainD
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEE D Y303 Y310 H313 D315 R322 V376 R383 W389 Y98 Y105 H108 D110 R117 V171 R178 W184
BS02 MN D H313 D315 H374 H108 D110 H169
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6zbn, PDBe:6zbn, PDBj:6zbn
PDBsum6zbn
PubMed33792169
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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