Structure of PDB 6yvs Chain D

Receptor sequence
>6yvsD (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
TRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTS
DSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFL
QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVK
LGDFLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNN
DVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI
LEEEKAQ
3D structure
PDB6yvs Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
ChainD
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PVT D R426 I428 A452 M499 C502 G505 L553 R15 I17 A41 M88 C91 G94 L142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6yvs, PDBe:6yvs, PDBj:6yvs
PDBsum6yvs
PubMed33497606
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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