Structure of PDB 6yca Chain D

Receptor sequence
>6ycaD (length=385) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
VTDIRFLQSRAEHERAFTVFWRAMVGLPELLELGRYLGAFVQGELIGGAD
SYTSWLTVPGGSRVPHAAVTHIGVLPTHTRRGILTALVTRQLTDIAGRGE
IVASLRASEAVIYRRFGYGIATSSATYRIQRRRAAPLRPIDTGAIALLDA
AASPEGLAAIYERAAWTGSVARPPQWWRLHELFDAADPVKPYVVTHPDGY
VRYRPQDTAEWFSSSARTISVDDLVAHSDEAYRALVGHLLDLDLVDVIEL
GPRPIDDPLPHLVTDPRAVAVAGIRDETWLRLVDVEAALAARTYTDGAPV
VIEVQDTLLPHNAARFSVSSDKVRRTQHTPDISVDVAALGSVYLGGNTWT
RLERAGLVSAQSPGAIRAADALFSTGTQPFAGTNF
3D structure
PDB6yca Structural analysis of the N-acetyltransferase Eis1 from Mycobacterium abscessus reveals the molecular determinants of its incapacity to modify aminoglycosides.
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO D D273 L274 D243 L244
BS02 ACO D A45 M46 I102 V104 T109 R110 G112 L114 T115 S138 E139 V141 I142 Y143 R145 A23 M24 I72 V74 T79 R80 G82 L84 T85 S108 E109 V111 I112 Y113 R115
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0034069 aminoglycoside N-acetyltransferase activity
Biological Process
GO:0030649 aminoglycoside antibiotic catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0044161 host cell cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yca, PDBe:6yca, PDBj:6yca
PDBsum6yca
PubMed32860271
UniProtA0A418LDP6

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