Structure of PDB 6xa2 Chain D

Receptor sequence
>6xa2D (length=398) Species: 529089 (Streptomyces sp. 307-9) [Search protein sequence]
PLELDDAFMQDPHSVYARLNAEGSAHRVMMPPGVPVCGGLPVWLITGYEE
VRSALADPRLSTDLNRTDRLFAQNEPDRNKRGAFSSALATHMLHSDPPDH
TRLRKLVNKAFTSRAIEKLRPEIEQITGELLAALPDEDPVDLLDAFAFPL
PIRVICLLLGVPNFKSWSKALVSGDSPAATAAASTAMIEYLGDLIERKRR
TPTDDVLAALVSARDVDDRLTETELVSMAFLLFIGGHETTVNTLGNGTLH
LMRNLDQWEALRQDRSLLPGAVEEFLRLESPLKHATFRCATEDLRIGDTA
IPAGDFVLLALASANRDPERFGDPHTLDVRRPTGGHVAFGHGIHYCLGAP
LARMEAQVAFGVLLDTFPAMRLAVDPEDMRWRTSTLIRGLHSLPVRLN
3D structure
PDB6xa2 Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.
ChainD
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S186 E251 T252 C359 L360 G361
Catalytic site (residue number reindexed from 1) S173 E238 T239 C346 L347 G348
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D M100 L101 H108 R112 G249 T252 A298 T299 R301 A351 F352 H357 C359 G361 A365 M92 L93 H100 R104 G236 T239 A285 T286 R288 A338 F339 H344 C346 G348 A352
BS02 V0A D L101 L184 V185 G248 L295 T299 S397 T398 L399 I400 L93 L171 V172 G235 L282 T286 S384 T385 L386 I387
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6xa2, PDBe:6xa2, PDBj:6xa2
PDBsum6xa2
PubMed33569241
UniProtD3Y1J3

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