Structure of PDB 6x91 Chain D

Receptor sequence
>6x91D (length=557) Species: 9606,83333 [Search protein sequence]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEKDLLPNPPKTWEEIPALDKELKAKGNLQEPYFTWPLIAG
KYDIKDVGVDNAGAKAGLTFLVDLADTDYSIAEAAFNKGETAMNGPWAWS
NIDTSKVNYGVTVLPTFKGQPSKPFVGVLSINAASPNKELAKEFLENYLL
TDEGLEAVNKDKPLGAVALKSYEEELVKDPRIAATMENAQKGEIMPNIPQ
MSAFWYAVRTAVINAASGRQTVDEALKDAQTNSSSRRRIEPWEFDVFYDP
RELRKEACLLYEIKWGASSKIWRSSGKNTTNHVAVNFIKKFTSERDFHPS
TSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLFAHMDQQNRQ
GLRDLVNSGVTIQIMRDSEYYHCWRNFVNYPPGDEAHWPQYPPAWMMLYA
LELHCIILSLPPCLKISRRAQNHLTAFRLHLQNCHYQTIPPHILLATGLI
HPSVAWR
3D structure
PDB6x91 The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
ChainD
Resolution3.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.36: mRNA(cytosine(6666)) deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC D E112 Y156 E111 Y142
BS02 GLC D W63 D66 R67 Y156 M331 W341 W62 D65 R66 Y142 M295 W305
BS03 GLC D A269 R1033 Q1200 A233 R354 Q521
BS04 GLC D A78 R1033 Q1200 A77 R354 Q521
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0016787 hydrolase activity
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0046872 metal ion binding
GO:1901982 maltose binding
Biological Process
GO:0006397 mRNA processing
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0010332 response to gamma radiation
GO:0015768 maltose transport
GO:0016554 cytidine to uridine editing
GO:0016556 mRNA modification
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042953 lipoprotein transport
GO:0042956 maltodextrin transmembrane transport
GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation
GO:0048255 mRNA stabilization
GO:0051649 establishment of localization in cell
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
GO:0090209 negative regulation of triglyceride metabolic process
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0030895 apolipoprotein B mRNA editing enzyme complex
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0045293 mRNA editing complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x91, PDBe:6x91, PDBj:6x91
PDBsum6x91
PubMed33094286
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P41238

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