Structure of PDB 6x3x Chain D

Receptor sequence
>6x3xD (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
DNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDME
YTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVA
HNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS
YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGE
YVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG
VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY
FTKSQPARAAKIDRLSRIAFPLLFGIFNLVYWATYLNR
3D structure
PDB6x3x Shared structural mechanisms of general anaesthetics and benzodiazepines.
ChainD
Resolution2.92 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN D N111 K117 N102 K108
BS02 ABU D F65 R67 F56 R58 BindingDB: Ki=21.37nM,EC50=3802nM
BS03 DZP D I228 L232 P233 L269 I219 L223 P224 L260 BindingDB: Ki=14nM,Kd=36nM,EC50=85nM
BS04 DZP D F100 H102 S159 Y160 S205 Y210 F91 H93 S150 Y151 S196 Y201 BindingDB: Ki=14nM,Kd=36nM,EC50=85nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x3x, PDBe:6x3x, PDBj:6x3x
PDBsum6x3x
PubMed32879488
UniProtP14867|GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=GABRA1)

[Back to BioLiP]