Structure of PDB 6wxu Chain D

Receptor sequence
>6wxuD (length=273) Species: 10090 (Mus musculus) [Search protein sequence]
ALGHTLPFYTGTKPTFPMDTTLAVIITIFLTALVTFIIILPGIRGKTRLF
WLLRVVTSLFIGAVILAVNFSSEWSVGHVNANTTYKAFSPKWVSVDVGLQ
IGLGGVNITLTGTPVQQLNETINYNEAFAWRLGRSYAEEYAKALEKGLPD
PVLYLAEKFTPRSPCGLYNQYRLAGHYASAMLWVAFLCWLLANVMLSMPV
LVYGGHMLLATGLFQLLALFFFSMTTSLISPCPLRLGTAVLHTHHGPAFW
ITLATGLLCILLGLVMAVAHRMQ
3D structure
PDB6wxu Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN D Y126 N127 E128 Y124 N125 E126
BS02 MAN D T123 N125 T121 N123
BS03 MAN D E122 T123 Y126 E120 T121 Y124
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0008104 protein localization
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process
GO:0015031 protein transport
GO:0042743 hydrogen peroxide metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0050727 regulation of inflammatory response
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000609 regulation of thyroid hormone generation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wxu, PDBe:6wxu, PDBj:6wxu
PDBsum6wxu
PubMed32929281
UniProtQ8VE49|DOXA1_MOUSE Dual oxidase maturation factor 1 (Gene Name=Duoxa1)

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