Structure of PDB 6wqx Chain D

Receptor sequence
>6wqxD (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
EAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGY
RHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIE
GSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSN
MLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETV
FEAFLKSYSTSSKKARPVLKKLDEVRLRGR
3D structure
PDB6wqx Crystal structure of the human PRPK-TPRKB complex.
ChainD
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D K60 M113 E115 I116 L169 I182 D183 K43 M96 E98 I99 L152 I165 D166
BS02 MG D N167 D183 N150 D166
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0008033 tRNA processing
GO:0016310 phosphorylation
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0000408 EKC/KEOPS complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:6wqx, PDBe:6wqx, PDBj:6wqx
PDBsum6wqx
PubMed33547416
UniProtQ96S44|PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (Gene Name=TP53RK)

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