Structure of PDB 6wjd Chain D

Receptor sequence
>6wjdD (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLV
IGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLNASVALHKHSNALV
DVLPPEADSSIMMSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYK
QIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGE
GPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLEL
LNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKR
LIFSTITSKMNLSEEVDLEDYVADKGADINSICQESGMLAVRENRYIVLA
KDFEKAYKTVIKKDEQEHEFYK
3D structure
PDB6wjd Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome.
ChainD
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS D P208 C210 G211 K212 T213 M214 G372 A373 P166 C168 G169 K170 T171 M172 G326 A327
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wjd, PDBe:6wjd, PDBj:6wjd
PDBsum6wjd
PubMed32783951
UniProtP43686|PRS6B_HUMAN 26S proteasome regulatory subunit 6B (Gene Name=PSMC4)

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