Structure of PDB 6wb7 Chain D

Receptor sequence
>6wb7D (length=294) Species: 134676 (Actinoplanes sp. SE50/110) [Search protein sequence]
HTDVLVLGGAGVDTIAYVPELPLPFQDSYVVAAIEPRAGQTGDNVALGLH
TLGLRTMHVDVLGDDPEGDLVRAFHTRHGLPFAALPTAAGTKRAVNLVGP
DGRRLSLWDGSREAEEDRYPAALIAAHTAHARHVHVCITPPGQHVFGQLN
DLPVTVSTDLHNWDGAYEGFEVYAFNADLVFLSATALTDVAATMRRVIDR
GRARLVVATDGAHGGSVLVRGETEVRRYAAVAPEAPVVDSNGAGDAFVSG
FLFGHLAGEPLETCLRYGAIAGAYACTIPATRAGAIDRAALLRP
3D structure
PDB6wb7 The human microbiome encodes resistance to the antidiabetic drug acarbose.
ChainD
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.187: acarbose 7(IV)-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC D I141 T142 F173 I138 T139 F170
BS02 AC1 D D16 Q43 T44 D248 D13 Q40 T41 D245
BS03 ANP D T212 G214 Y231 A246 G247 D248 C279 T209 G211 Y228 A243 G244 D245 C276
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0016310 phosphorylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wb7, PDBe:6wb7, PDBj:6wb7
PDBsum6wb7
PubMed34819672
UniProtQ8RMD4|ACBK_ACTS5 Acarbose 7(IV)-phosphotransferase (Gene Name=acbK)

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