Structure of PDB 6waa Chain D

Receptor sequence

>6waaD (length=637) Species: 507522 (Klebsiella pneumoniae 342)

LPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILN
TWEVSSDEVLASQEVHDISVAIGIDPDSDYGKICILADADSDGLHIATLL
CALFVRHFRTLVKEGHVYVALPPLYALTEEEKTGVRFKGLGEMNPMQLRE
TTLDPNTRRLVQLISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEKGRLAL
HEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPD
DPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPAR
LPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIV
QGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVALPHQVSGAKVLEQIA
AQMRNKKLPMVDDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLL
EILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIR
TEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKER
DQLQAILASERKMNNLLKKELQADADAFGDDRRSPLH

3D structure

• PDB: 6waa Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
• Chain: D
• Resolution: 3.2 Å

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	L446 N447 S459 H498 K610 Y1120 I1172 A1173 G1175 M1176 T1318 S1324 R1326	L49 N50 S62 H95 K182 Y310 I362 A363 G365 M366 T474 S480 R482
BS02	dna	D	G443 D495 R1029 V1041 H1075 H1077 G1078 A1081 T1170 I1172	G46 D92 R219 V231 H265 H267 G268 A271 T360 I362
BS03	TNJ	D	K442 E461 S1080	K45 E64 S270

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006265 DNA topological change

Cellular Component

• GO:0005694 chromosome

External links

• PDB: RCSB:6waa, PDBe:6waa, PDBj:6waa
• PDBsum: 6waa
• PubMed: 32634310
• UniProt: B5XU60