Structure of PDB 6vw7 Chain D

Receptor sequence

>6vw7D (length=514) Species: 106590 (Cupriavidus necator)

MITITTIFVPRDSTALALGADDVARAIAREAAARNEHVRIVRNGSRGMFW
LEPLVEVQTGAGRVAYGPVSAADVPGLFDAGLLQGGEHALSQGVTEEIPF
LKQQERLTFARVGITDPLSLDDYRAHEGFAGLERALAMQPAEIVQEVTDS
GLRGRGGAAFPTGIKWKTVLGAQSAVKYIVCNADEGDSGTFSDRMVMEDD
PFMLIEGMTIAALAVGAEQGYIYCRSEYPHAIAVLESAIGIANAAGWLGD
DIRGSGKRFHLEVRKGAGAYVCGEETALLESLEGRRGVVRAKPPLPALQG
LFGKPTVINNVISLATVPVILARGAQYYRDYGMGRSRGTLPFQLAGNIKQ
GGLVEKAFGVTLRELLVDYGGGTRSGRAIRAVQVGGPLGAYLPESRFDVP
LDYEAYAAFGGVVGHGGIVVFDETVDMAKQARYAMEFCAIESCGKCTPCR
IGSTRGVEVMDRIIAGEQPVKHVALVRDLCDTMLNGSLCAMGGMTPYPVL
SALNEFPEDFGLAS

3D structure

• PDB: 6vw7 Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG fromCupriavidus necator.
• Chain: D
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.2: Transferred entry: 1.17.1.9.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	D	G154 G156 K165 N182 E185 G273 E274 E275 N309 N310 S313 A490 M491	G154 G156 K165 N182 E185 G273 E274 E275 N309 N310 S313 A490 M491
BS02	SF4	D	V271 V289 S442 C443 G444 K445 C446 C449 L488 C489 M491 G492	V271 V289 S442 C443 G444 K445 C446 C449 L488 C489 M491 G492
BS03	NAI	D	A158 F160 K165 T168 E275 L295	A158 F160 K165 T168 E275 L295	MOAD: Kd=190uM

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:1902600 proton transmembrane transport

External links

• PDB: RCSB:6vw7, PDBe:6vw7, PDBj:6vw7
• PDBsum: 6vw7
• PubMed: 32249211
• UniProt: Q0KDY2