Structure of PDB 6vuq Chain D

Receptor sequence
>6vuqD (length=159) Species: 37124 (Chikungunya virus) [Search protein sequence]
PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATP
VGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGV
NSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKK
ISEAIQMRT
3D structure
PDB6vuq Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
ChainD
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR D D11 I12 A23 A24 N25 G31 D32 G33 V34 C35 L109 S111 T112 G113 V114 Y115 R145 D9 I10 A21 A22 N23 G29 D30 G31 V32 C33 L107 S109 T110 G111 V112 Y113 R143
External links
PDB RCSB:6vuq, PDBe:6vuq, PDBj:6vuq
PDBsum6vuq
PubMed33482665
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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