Structure of PDB 6v6z Chain D

Receptor sequence
>6v6zD (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLL
YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGH
IYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA
VGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG
YDGQDQLNSVERYDVATATWTFVAPMKHRRSALGITVHQGRIYVLGGYDG
HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
3D structure
PDB6v6z Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.
ChainD
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q5Y D Y334 S363 N382 N414 R415 S508 Y525 Q530 S555 A556 Y572 F577 S602 G603 Y10 S39 N58 N90 R91 S184 Y201 Q206 S231 A232 Y248 F253 S278 G279 MOAD: ic50=63nM
BindingDB: IC50=110nM
External links
PDB RCSB:6v6z, PDBe:6v6z, PDBj:6v6z
PDBsum6v6z
PubMed32292559
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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