Structure of PDB 6v4l Chain D

Receptor sequence
>6v4lD (length=448) Species: 223926 (Vibrio parahaemolyticus RIMD 2210633) [Search protein sequence]
IILGAGQVGGTLAENLVGENNDITIVDNNADRLRELQDKLRVVNGHASHP
DVLHEAGAQDLVAVTNTDETNMAACQVAFTLFNTPNRVARIRSPEYLAEK
EALFKSGAIPVDHLIAPEELVTSYIERLIQYPGALQVVSFAEQKVSLVAV
KAYYGGPLVGNALSALREHMPHIDTRVAAIFRQGRPIRPQGTTIIEADDE
VFFVAASNHIRSVMSELQRLEKPYRRIMIVGGGNIGASLAKRLEQTYSVK
LIERDYQRAEKLSEQLENTIVFCGDAADQELLTEENIDQVDVFIALTNED
ETNIMSAMLAKRMGAKKVMVLIQRGAYVDLVQGGVIDVAISPQQATISAL
LTHVRRADIVNVSSLRRGAAEAIEAVAHGDETTSKVVGRAIGDIKLPPGT
TIGAVVRGEEVLIAHDRTVIEQDDHVVMFLVDKKYVPDVEALFQPSPF
3D structure
PDB6v4l TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential.
ChainD
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS D V238 G241 I243 E261 R262 N306 Q331 V230 G233 I235 E253 R254 N298 Q323
BS02 AGS D G9 Q10 D30 A52 N74 R98 G6 Q7 D27 A47 N66 R90
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v4l, PDBe:6v4l, PDBj:6v4l
PDBsum6v4l
PubMed31992706
UniProtQ87KD2

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