Structure of PDB 6ux0 Chain D

Receptor sequence
>6ux0D (length=414) Species: 1257118 (Acanthamoeba castellanii str. Neff) [Search protein sequence]
KYGDIFTMKVFGQRLTFLVGPDAHVPFFSQGDAELSQDEPYQFSVPIFGP
NVVYGADLAHRNQQLKFIAASLSTKALQSYVPLIVKEAEDFFAKWDKSGT
VDIRDALAELIILTASRCLMGKEIRENLFTEVAKLYQTLDEGLLPISVFF
PYLPIPAHKRRDEARLAMVRMFKKIIDERRANPEVKHNDCLQVFMDARYR
GEEQALNDEEITGLMIALLFAGQHTSSVTGSWTGLLLFEANNKKKFLPGV
LEEQEEIRKEFGDELTMEALNKMDKLHRCVKEALRMYPPLLFVMRKVIKP
FSYKDYYVPEGDTVFVSPALSMRVEEVFPNADQYNPERFVEEDKQAQKYR
FVGFGAGRHGCMGENFAYLQIKTIWSVLLRNFDIELVGELPKPDYTAMVV
GPAHPCLLRYTRKH
3D structure
PDB6ux0 Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.
ChainD
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D Q110 Y114 T298 S299 T302 V366 R368 G426 F427 G428 H432 C434 G436 Q37 Y41 T225 S226 T229 V293 R295 G353 F354 G355 H359 C361 G363
BS02 QKM D Y114 F116 F121 Y127 A290 F293 A294 T298 L363 M367 M471 Y41 F43 F48 Y54 A217 F220 A221 T225 L290 M294 M398
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008168 methyltransferase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6ux0, PDBe:6ux0, PDBj:6ux0
PDBsum6ux0
PubMed33008918
UniProtL8GJB3

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