Structure of PDB 6usa Chain D

Receptor sequence
>6usaD (length=404) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
AIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQD
FLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKIN
NVLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDT
ARQALNVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFG
TAAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIG
IFHAFLDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQD
EDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLL
CRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKW
FGLL
3D structure
PDB6usa Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.
ChainD
Resolution2.406 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K101 E123 S390
Catalytic site (residue number reindexed from 1) K98 E120 S387
Enzyme Commision number 4.2.1.20: tryptophan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PZJ D F188 W191 Y200 F202 P208 F211 H294 F185 W188 Y197 F199 P205 F208 H291
BS02 P1T D H100 K101 T124 G125 A126 G127 Q128 H129 T204 G246 G248 S249 N250 G317 E364 S390 G391 H97 K98 T121 G122 A123 G124 Q125 H126 T201 G243 G245 S246 N247 G314 E361 S387 G388
Gene Ontology
Molecular Function
GO:0004834 tryptophan synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
GO:1901605 alpha-amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usa, PDBe:6usa, PDBj:6usa
PDBsum6usa
PubMed31930594
UniProtP9WFX9|TRPB_MYCTU Tryptophan synthase beta chain (Gene Name=trpB)

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