Structure of PDB 6uqe Chain D

Receptor sequence

>6uqeD (length=578) Species: 83333 (Escherichia coli K-12)

MENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGV
GKTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFK
ALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRV
IGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAH
HDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRK
KTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIE
ALTEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLR
FDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEK
AHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIG
LIHQDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVE
LQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLAN
ELLFGSLVDGGQVTVALDKEKNELTYGF

3D structure

• PDB: 6uqe Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
• Chain: D
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	K258 Y259	K90 Y91
BS02	peptide	D	G539 V541	G371 V373
BS03	AGS	D	L188 I189 S216 G217 G219 K220 T221 I357 L361	L20 I21 S48 G49 G51 K52 T53 I189 L193
BS04	AGS	D	V460 F461 T497 G498 V499 G500 K501 T502 E503 N606 K664 F665 A701 R702	V292 F293 T329 G330 V331 G332 K333 T334 E335 N438 K496 F497 A533 R534

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:6uqe, PDBe:6uqe, PDBj:6uqe
• PDBsum: 6uqe
• PubMed: 32313240
• UniProt: P0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)