Structure of PDB 6uiw Chain D

Receptor sequence
>6uiwD (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
SLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIG
VPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAV
APVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPC
KENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPL
SYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEE
LIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGL
3D structure
PDB6uiw The structures and gating mechanism of human calcium homeostasis modulator 2.
ChainD
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R2R D F39 W117 R124 F27 W105 R112
Gene Ontology
Molecular Function
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0043065 positive regulation of apoptotic process
GO:0048167 regulation of synaptic plasticity
GO:0070509 calcium ion import
GO:0098655 monoatomic cation transmembrane transport
GO:1903978 regulation of microglial cell activation
GO:1904669 ATP export
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6uiw, PDBe:6uiw, PDBj:6uiw
PDBsum6uiw
PubMed31776515
UniProtQ9HA72|CAHM2_HUMAN Calcium homeostasis modulator protein 2 (Gene Name=CALHM2)

[Back to BioLiP]