Structure of PDB 6u9x Chain D

Receptor sequence

>6u9xD (length=294) Species: 5691 (Trypanosoma brucei) [Search protein sequence]

VHLSTIQLEKLSHPPARFDNSFVYKWQTKAALARKVSGPMREWAAELKYR
TGVHIELEPTYPERLSENAVQWGAYETADDVDITVYLFGSERGIFNCHKL
MEAAIQQDPVYVRLGIFRRLANSSEVEWLMLRRINRELRPPDIPPISLKL
PGKWTLLYERYKEAAIRTLWEETGITVDASNVYPTGHLYQTVPQYYWRVP
VRYFVAEVPSDIRVEGPQVVPLQYMRNWDARLLRQSPDPIDRAWAQLADP
ATGCAWMKASMIDQLQKPLRGDNYMAIRYTPPPYSNLQEVVGLG

3D structure

PDB

6u9x Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	S112 M115 R116 Y197 R199 R219 N221 R222 L224 P226 I229 I232 S233 L234 K235 L274 Y275 Q276 W283 V285 V287 Y289 I326 Q352 L355 R356 Y360 R364	S37 M40 R41 Y111 R113 R133 N135 R136 L138 P140 I143 I146 S147 L148 K149 L188 Y189 Q190 W197 V199 V201 Y203 I240 Q266 L269 R270 Y274 R278	PDBbind-CN: Kd=40nM

External links

PDB	RCSB:6u9x, PDBe:6u9x, PDBj:6u9x
PDBsum	6u9x
PubMed	31704716
UniProt	B6SBM0

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