Structure of PDB 6u90 Chain D

Receptor sequence
>6u90D (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSASIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB6u90 Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
ChainD
Resolution3.00082 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D C651 N652 S655 V657 E697 V699 R731 R733 Q772 T773 T776 K777 G784 G831 C89 N90 S93 V95 E135 V137 R169 R171 Q210 T211 T214 K215 G222 G269
BS02 dna D V657 P659 V95 P97
BS03 SAH D F581 D582 G583 I584 T586 E605 V606 D627 V628 G648 R832 S833 W834 F19 D20 G21 I22 T24 E43 V44 D65 V66 G86 R270 S271 W272 BindingDB: IC50=300nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6u90, PDBe:6u90, PDBj:6u90
PDBsum6u90
PubMed
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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