Structure of PDB 6u6x Chain D

Receptor sequence
>6u6xD (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRIDVAKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRR
AYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKL
TDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRED
YESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDIDHVSFYCAEQLIRVY
CKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB6u6x Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
ChainD
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D V117 I118 H125 D137 R145 V4 I5 H12 D24 R32
BS02 dna D Y155 V156 R371 R372 H376 K377 V378 R451 Y42 V43 R249 R250 H254 K255 V256 R329
BS03 ZN D H167 H206 D207 H54 H93 D94
External links
PDB RCSB:6u6x, PDBe:6u6x, PDBj:6u6x
PDBsum6u6x
PubMed33531504
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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