Structure of PDB 6u2h Chain D

Receptor sequence
>6u2hD (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK
FEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGL
ATVKSRWSGSEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELM
TGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKK
RDERPSFPRILAEIEELARELPKIHRSASEPSL
3D structure
PDB6u2h Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D129 K131 N133 N134 D147 S166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 29L D V471 K483 E501 T529 W531 C532 N580 F583 D594 V24 K36 E54 T82 W84 C85 N133 F136 D147 BindingDB: IC50=0.170000nM,Ki=0.130000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6u2h, PDBe:6u2h, PDBj:6u2h
PDBsum6u2h
PubMed31988522
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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