Structure of PDB 6u1h Chain D

Receptor sequence
>6u1hD (length=305) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
EMRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKA
LTALEAKAAPEGEHPFPPPLSWERYDVVFPLLHGRFGEDGTVQGFLELLG
KPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPVVPFDPP
FFVKPANTGGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGV
LGNVFGEASPVGEVRELLIPAPLDPGTQETVQELALKAYKVLGVRGMARV
DFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT
HHHHH
3D structure
PDB6u1h d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V16 L19 H82 R268 G288 T292
Catalytic site (residue number reindexed from 1) V17 L20 H83 R249 G269 T273
Enzyme Commision number 6.3.2.4: D-alanine--D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP D F151 K153 G158 I163 L192 E197 F272 N281 E282 F152 K154 G159 I161 L190 E195 F253 N262 E263
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6u1h, PDBe:6u1h, PDBj:6u1h
PDBsum6u1h
PubMed32335509
UniProtQ5SHZ3|DDL_THET8 D-alanine--D-alanine ligase (Gene Name=ddl)

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