Structure of PDB 6tz6 Chain D

Receptor sequence
>6tz6D (length=352) Species: 294748 (Candida albicans WO-1) [Search protein sequence]
RAVKSVDPPATFKPKDEQVFYPNGKPNHQFLKQHFIHEGRLHEHQAIQIL
KQATHLLSKEPNLLSVPAPVTICGDVHGQYYDLMKLFEVGGDPASTKYLF
LGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNE
CLHKYSEELYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKL
HRFREPPTKGLMCDLLWADPIEEYDDDNLDQEYVTNVVRGCSFAFTYKAA
CKFLDRTKLLSVIRAHEAQNAGYRMYKRTKFPSLLTMFSAPNYLDSYNNK
AAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSI
LN
3D structure
PDB6tz6 Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
ChainD
Resolution2.55 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D D167 N199 H248 H330 D103 N135 H184 H266
BS02 FE D D139 H141 D167 D75 H77 D103
BS03 FK5 D W401 S402 P404 F405 E408 W334 S335 P337 F338 E341
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6tz6, PDBe:6tz6, PDBj:6tz6
PDBsum6tz6
PubMed31537789
UniProtC4YFI3

[Back to BioLiP]