Structure of PDB 6txr Chain D

Receptor sequence
>6txrD (length=306) Species: 5855 (Plasmodium vivax) [Search protein sequence]
PKPKIVLVGSGMIGGVMATLIVQKNLGDVVMFDVVKNMPQGKALDTSHSN
VMAYSNCKVTGSNSYDDLKGADVVIVTAGFTKANRDDLLPLNNKIMIEIG
GHIKNLCPNAFIIVVTNPVDVMVQLLFEHSGVPKNKIIGLGGVLDTSRLK
YYISQKLNVCPRDVNALIVGAHGNKMVLLKRYITVGGIPLQEFINNKKIT
DEEVEGIFDRTVNTALEIVNLLASPYVAPAAAIIEMAESYLKDIKKVLVC
STLLEGQYGHSNIFGGTPLVIGGTGVEQVIELQLNAEEKTKFDEAVAETK
RMKALI
3D structure
PDB6txr Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O0Q D L231 L232 L221 L222
BS02 DA D V36 Y67 A80 G81 F82 I105 V34 Y65 A78 G79 F80 I95
BS03 DG D G13 V37 M40 G11 V35 M38
BS04 DU D G13 M14 G11 M12
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6txr, PDBe:6txr, PDBj:6txr
PDBsum6txr
PubMed32631977
UniProtQ4PRK9

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