Structure of PDB 6tvn Chain D

Receptor sequence
>6tvnD (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVILESIFLKRSQNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVE
KITCVETVVPEKNPPPERQIEQISIIERFPYPFQVVYDEGPLYVFSPTEE
LRKRWIHQLKNVIRYNSDLVQKYHPAFWIDGQYLCCSQTAKNAMGCQI
3D structure
PDB6tvn Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
ChainD
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NYQ D K12 Q15 Y39 I56 L111 K11 Q14 Y30 I47 L92
BS02 ZN D H143 C155 C165 H124 C136 C146
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6tvn, PDBe:6tvn, PDBj:6tvn
PDBsum6tvn
PubMed
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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