Structure of PDB 6tuh Chain D

Receptor sequence
>6tuhD (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVILESIFLKRSLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVE
KITCVETVVPEKNPPPERQIEQISIIERFPYPFQVVYDEGPLYVFSPTEE
LRKRWIHQLKNVIRYNSDLVQKYHPSFWIDGQYLCCSQTAKNAMGCQ
3D structure
PDB6tuh Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
ChainD
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXT D K12 R28 Y39 K53 K11 R19 Y30 K44
BS02 ZN D H143 C154 C155 C165 H124 C135 C136 C146
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6tuh, PDBe:6tuh, PDBj:6tuh
PDBsum6tuh
PubMed
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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