Structure of PDB 6t8e Chain D

Receptor sequence
>6t8eD (length=436) Species: 73868 (Piromyces sp. E2) [Search protein sequence]
AKEYFPQIQKIKFEGKDSKNPLAFHYYDAEKEVMGKKMKDWLRFAMAWWH
TLCAEGADQFGGGTKSFPWNEGTDAIEIAKQKVDAGFEIMQKLGIPYYCF
HDVDLVSEGNSIEEYESNLKAVVAYLKEKQKETGIKLLWSTANVFGHKRY
MNGASTNPDFDVVARAIVQIKNAIDAGIELGAENYVFWGGREGYMSLLNT
DQKREKEHMATMLTMARDYARSKGFKGTFLIEPKPMEPTKHQYDVDTETA
IGFLKAHNLDKDFKVNIEVNHATLAGHTFEHELACAVDAGMLGSIDANRG
DYQNGWDTDQFPIDQYELVQAWMEIIRGGGFVTGGTNFDAKTRRNSTDLE
DIIIAHVSGMDAMARALENAAKLLQESPYTKMKKERYASFDSGIGKDFED
GKLTLEQVYEYGKKNGEPKQTSGKQELYEAIVAMYQ
3D structure
PDB6t8e Structure-based directed evolution improves S. cerevisiae growth on xylose by influencing in vivo enzyme performance.
ChainD
Resolution1.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H102 D105 W140 E233 K235 E269 H272 D297 D308 D310 D340
Catalytic site (residue number reindexed from 1) H101 D104 W139 E232 K234 E268 H271 D296 D307 D309 D339
Enzyme Commision number 5.3.1.5: xylose isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D E233 E269 D297 D340 E232 E268 D296 D339
BS02 CA D E269 H272 D308 D310 E268 H271 D307 D309
BS03 XLS D W50 H102 W189 E233 D340 W49 H101 W188 E232 D339
BS04 XYP D G64 K66 S67 G63 K65 S66
BS05 XYS D K204 H258 K203 H257
BS06 XYS D D41 Y98 K137 D40 Y97 K136
BS07 XYP D Q10 L23 Q9 L22
Gene Ontology
Molecular Function
GO:0009045 xylose isomerase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0042732 D-xylose metabolic process
GO:0044577 D-xylose catabolic process to ethanol

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Molecular Function
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Biological Process
External links
PDB RCSB:6t8e, PDBe:6t8e, PDBj:6t8e
PDBsum6t8e
PubMed31938040
UniProtQ9P8C9

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