Structure of PDB 6t6n Chain D

Receptor sequence
>6t6nD (length=244) Species: 1420013 (Klebsiella pneumoniae 30684/NJST258_2) [Search protein sequence]
MALASKTAIVTGAARGIGFGIAQVLAREGARVIIADRDAHGEAAAASLRE
SGAQALFISCNIAEKTQVEALFSQAEEAFGPVDILVNNAGINRDAMLHKL
TEADWDTVIDVNLKGTFLCMQQAAIRMRERGAGRIINIASASWLGNVGQT
NYSASKAGVVGMTKTACRELAKKGVTVNAICPGFIDTDMTRGVPENVWQI
MISKIPAGYAGEAKDVGECVAFLASDGARYINGEVINVGGGMVL
3D structure
PDB6t6n A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 S140 Y152
Catalytic site (residue number reindexed from 1) G16 S140 Y152
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI D G12 R15 G16 I17 D36 R37 C60 N61 I62 N88 A89 G90 V111 S140 Y152 K156 P182 I185 T187 T190 G12 R15 G16 I17 D36 R37 C60 N61 I62 N88 A89 G90 V111 S140 Y152 K156 P182 I185 T187 T190
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6t6n, PDBe:6t6n, PDBj:6t6n
PDBsum6t6n
PubMed33388594
UniProtW8VGR4

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