Structure of PDB 6t65 Chain D

Receptor sequence
>6t65D (length=213) Species: 470 (Acinetobacter baumannii) [Search protein sequence]
RKVALVTGASRGIGAAIAQQLIQDGYFVVGTATSESGAQKLTDSFGEQGA
GLALDVRNLDEIEAVVSHIEQNYGPVLVLVNNALLRMSEDDWDDILNIHL
KAVYRLSKRVLKGMTKARFGRIINISSVVAHNYSAAKAGIEAFSRSLAKE
MGSRQITVNSVAPGFIAKMSDQVALNRLGEPQDIANAVSFLASDKAGYIT
GTVLHVNGGLYMA
3D structure
PDB6t65 A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
ChainD
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 S138 Y151
Catalytic site (residue number reindexed from 1) G12 S127 Y133
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MLH D L107 L111 K112 G157 F161 L96 L100 K101 G139 F143
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0051287 NAD binding
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6t65, PDBe:6t65, PDBj:6t65
PDBsum6t65
PubMed33388594
UniProtV5VHN7

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