Structure of PDB 6sqw Chain D

Receptor sequence
>6sqwD (length=112) Species: 10090 (Mus musculus) [Search protein sequence]
MPFRFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAEL
FQWKSDTEPGPQAWPPKERAALQEELSDVLIYLVALAARCHVDLPQAVIS
KMDTNRQRYPVH
3D structure
PDB6sqw The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
ChainD
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.12: dCTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D E63 E66 E95 D98 E43 E46 E75 D78
BS02 5CM D H38 F41 W47 H51 D98 Y102 H18 F21 W27 H31 D78 Y82
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0032556 pyrimidine deoxyribonucleotide binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0047429 nucleoside triphosphate diphosphatase activity
GO:0047840 dCTP diphosphatase activity
Biological Process
GO:0006253 dCTP catabolic process
GO:0009143 nucleoside triphosphate catabolic process
GO:0042262 DNA protection
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sqw, PDBe:6sqw, PDBj:6sqw
PDBsum6sqw
PubMed31954130
UniProtQ9QY93|DCTP1_MOUSE dCTP pyrophosphatase 1 (Gene Name=Dctpp1)

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