Structure of PDB 6sqo Chain D

Receptor sequence
>6sqoD (length=62) Species: 9606 (Homo sapiens) [Search protein sequence]
LPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCR
QPIQMIVLTYFP
3D structure
PDB6sqo Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
ChainD
Resolution1.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C438 C441 C461 C464 C9 C12 C32 C35
BS02 ZN D H452 H457 C475 C478 H23 H28 C46 C49
Gene Ontology
Molecular Function
GO:0042802 identical protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sqo, PDBe:6sqo, PDBj:6sqo
PDBsum6sqo
PubMed32350255
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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